The Collaborative Cross,developing a resource for mammalian systems genetics: A status report of the Wellcome Trust cohort |
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| Authors: | Fuad A Iraqi Gary Churchill Richard Mott |
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| Institution: | (1) Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel;(2) The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA;(3) Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK |
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| Abstract: | We report on the progress of a project funded by the Wellcome Trust to produce over 100 recombinant inbred mouse lines as
part of the Collaborative Cross (CC) genetic reference panel. These new strains of mice are being derived from a set of eight
genetically diverse founders. The genomes of the finished strains will be mosaics of the founder strains’ genomes with a high
density of independent recombination breakpoints. The CC mice will be available for distribution free of any intellectual
property constraints to serve as a community resource for systems genetics studies. |
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