Modulation of ovarian ornithine decarboxylase activity during follicular differentiation/maturation |
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Authors: | Usha Natraj |
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Institution: | (1) Department of Developmental and Reproductive Biology, University of Michigan, 48109 Ann Arbor, Michigan, USA;(2) Present address: Institute for Research in Reproduction, Jehangir Merwanji Street, Parel, 400 012 Bombay, India |
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Abstract: | The role of gonadotropins and estrogen on the regulation of ovarian ornithine decarboxylase was studied during follicular
differentiation/maturation. In intact immature rats follicular differentiation/maturation was initiated with sequential administration
of estrogen and follicle stimulating hormone. Ornithine decarboxylase activity in response to human chorionic gonadotropin
was markedly enhanced (2-fold) in rats with preovulatory antral follicles when compared to rats with non-ovulatory follicles.
This increase could be attributed to the alteration in the turnover of the enzyme. Following follicle maturation the half
life of the human chorionic gonadotropin stimulated ornithine decarboxylase was increased from 18 to 62 min. This increase
in half life was associated with differentition of follicles. In the estrogen treated group (which does not induce follicular
differentiation), the half life of the enzyme remained unaltered. The regulation of ornithine decarboxylase through the formation
of protein inhibitor antizyme induced by diamino hexane, was unaltered during follicular differentiation. |
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Keywords: | Ovarian ornithine decarboxylase follicular maturation half life antizyme |
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