Immobilised zinc (II) cyclen complexes as catalytic reagents for phosphodiester hydrolysis |
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Authors: | Thomas Walenzyk |
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Affiliation: | Institute for Organic Chemistry, University of Regensburg, D-93040 Regensburg, Germany |
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Abstract: | Many hydrolases found in nature have Zn(II) ions at their active site. Artificial hydrolases as alternatives for non-enzymatic hydrolysis were prepared by attaching Zn(II) cyclen complexes with an alcohol pendant to a polymeric support. These modified polymers showed a 104-fold enhanced intrinsic reactivity for the hydrolysis of activated phosphodiesters over the non-catalysed reaction in solution. |
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Keywords: | Phosphoester hydrolysis Immobilised metal complexes Zinc (II) cyclen |
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