Complexes of the {ReOX2} (X = Cl, Br) core with single amino acid chelate derivatives |
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Authors: | Lihui Wei John Babich |
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Affiliation: | a Department of Chemistry, Syracuse University, Syracuse, NY 13244, USA b Molecular Insight Pharmaceuticals Inc., 160 Second Street, Cambridge, MA 02142, USA |
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Abstract: | The reactions of 1 equiv. of the ligand 3-(ethoxycarbonylmethyl-pyridin-2-ylmethyl-amino)-propionic acid methyl ester (2) with the Re(V) starting materials [ReOX3(PPh3)2] (X = Cl, Br) in refluxing chloroform yielded the Re(V)-oxo dihalide complexes [ReOX2{(C5H4NCH2)N(CH2CO2)(C2H4CO2CH3)}] (X = Cl, 3; X = Br, 4). The complexes were characterized by elemental analysis, NMR and IR spectroscopy, cyclic voltammetry and X-ray crystallography. Complex 3 displays distorted octahedral coordination geometry with the tridentate ligand coordinating facially to the Re(V) center. The carboxylate oxygen atom occupies an axial site trans to the ReO bond. The two chlorine atoms consequently adopt a cis configuration. |
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Keywords: | {ReVOX2}+ core Single amino acid chelates Radiopharmaceutical design |
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