| New Cytotoxic Saponins from Lysimachia davurica Ledeb. |
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| 作者姓名： | Jing-Kui Tian Zhong-Mei Zou Li-Zhen Xu Shi-Lin Yang |
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| 作者单位： | [1]Department of Chinese Medicine Sciences and Engineering, Zhejiang University, Hangzhou 310028, China [2]Institute of Medicinal Plants Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China |
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| 摘 要： | To investigate the saponins from whole plants of Lysimachia davurica Ledeb., two new saponins named davuricoside I （compound 1） and E （compound 2） were isolated. Their chemical structures were elucidated as 3β, 16α, 28, 29-tetrihydroxy-olean-12-en-3-O-β-D-glucopyranosyl-（1→2）-β-D-glucuronopyranoside （compound 1） and 3β, 16α, 29-trihydroxy-13, 28-epoxy-oleanane-3-O-β-D-glucopyranosyl-（1→2）-β-D-glucuronopyranoside （compound 2） on the basis of their one- and two-dimensional nuclear magnetic resonance and mass spectrometry data, and chemical methods. Compound 1 showed significant cytotoxic activity against human A2780 cells.
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| 关 键 词： | 细胞毒素 皂苷类 金钱草 植物学 |
| 收稿时间： | 2005-03-24 |
| 修稿时间： | 2005-03-242005-06-02 |
New Cytotoxic Saponins from Lysimachia davurica Ledeb. |
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| Authors: | Jing-Kui Tian Zhong-Mei Zou Li-Zhen Xu Shi-Lin Yang |
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| Institution: | Department of Chinese Medicine Sciences and Engineering, Zhejiang University, Hangzhou 310028, China;;Institute of Medicinal Plants Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China |
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| Abstract: | To investigate the saponins from whole plants of Lysimachia davurica Ledeb., two new saponins named davuricoside I (compound 1) and E (compound 2) were isolated. Their chemical structures were elucidated as 3β,16α, 28, 29-tetrihydroxy-olean-12-en-3-O-β-D-glucopyranosyl-(1-→2)-β-D-glucuronopyranoside (compound 1)and 3β,16α, 29-trihydroxy-13, 28-epoxy-oleanane-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranoside (compound 2) on the basis of their one- and two-dimensional nuclear magnetic resonance and mass spectrometry data, and chemical methods. Compound 1 showed significant cytotoxic activity against human A2780 cells. |
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| Keywords: | davuricoside I and E Lysimachia davurica triterpene saponin |
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