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New Cytotoxic Saponins from Lysimachia davurica Ledeb.
作者姓名:Jing-Kui  Tian  Zhong-Mei  Zou  Li-Zhen  Xu  Shi-Lin  Yang
作者单位:[1]Department of Chinese Medicine Sciences and Engineering, Zhejiang University, Hangzhou 310028, China [2]Institute of Medicinal Plants Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
摘    要:To investigate the saponins from whole plants of Lysimachia davurica Ledeb., two new saponins named davuricoside I (compound 1) and E (compound 2) were isolated. Their chemical structures were elucidated as 3β, 16α, 28, 29-tetrihydroxy-olean-12-en-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranoside (compound 1) and 3β, 16α, 29-trihydroxy-13, 28-epoxy-oleanane-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranoside (compound 2) on the basis of their one- and two-dimensional nuclear magnetic resonance and mass spectrometry data, and chemical methods. Compound 1 showed significant cytotoxic activity against human A2780 cells.

关 键 词:细胞毒素  皂苷类  金钱草  植物学
收稿时间:2005-03-24
修稿时间:2005-03-242005-06-02

New Cytotoxic Saponins from Lysimachia davurica Ledeb.
Authors:Jing-Kui Tian  Zhong-Mei Zou  Li-Zhen Xu  Shi-Lin Yang
Institution:Department of Chinese Medicine Sciences and Engineering, Zhejiang University, Hangzhou 310028, China;;Institute of Medicinal Plants Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
Abstract:To investigate the saponins from whole plants of Lysimachia davurica Ledeb., two new saponins named davuricoside I (compound 1) and E (compound 2) were isolated. Their chemical structures were elucidated as 3β,16α, 28, 29-tetrihydroxy-olean-12-en-3-O-β-D-glucopyranosyl-(1-→2)-β-D-glucuronopyranoside (compound 1)and 3β,16α, 29-trihydroxy-13, 28-epoxy-oleanane-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranoside (compound 2) on the basis of their one- and two-dimensional nuclear magnetic resonance and mass spectrometry data, and chemical methods. Compound 1 showed significant cytotoxic activity against human A2780 cells.
Keywords:davuricoside I and E  Lysimachia davurica  triterpene saponin
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