Epidermal Growth Factor Induces Proliferation and DNA Synthesis in Ciliate Cells |
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| Authors: | Selivanova G V Shemarova I V Vlasova T D |
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| Institution: | (1) Russian Academy of Sciences, Institute of Cytology, Tikhoretskii pr. 4, St. Petersburg, 194064, Russia;(2) Russian Academy of Sciences, Sechenov Institute of Evolutionary Physiology and Biochemistry, pr. Morisa Toreza 44, St. Petersburg, 194223, Russia |
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| Abstract: | We studied the effect of murine epidermal growth factor on cell proliferation and DNA synthesis in macronuclei of ciliate Tetrahymena pyriformis Gl. Mitogenic effect of epidermal growth factor on proliferation-induced tetrahymena cells has been revealed. This effect is due to the induced progression of cells at G
1 and, consequently, their earlier entering DNA synthesis phase of the first cell cycle. Epidermal growth factor had no mitogenic effect on the resting cells in a stationary culture (G
0 phase) whose development is independent of the growth factors in the medium. |
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| Keywords: | proliferation DNA synthesis Tetrahymena pyriformis epidermal growth factor cell cycle |
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