Elimination of multidrug-resistant plasmid in bacteria by plumbagin,a compound derived from a plant |
| |
Authors: | V V Lakhmi Sridhar Padma Dr H Polasa |
| |
Institution: | (1) Department of Microbiology, Osmania University, 500007 Hyderabad, India |
| |
Abstract: | Plumbagin (5-hydroxy-2-methyl-1,4-naphthaquinone), a compound derived from the root of thePlumbago zeylanica plant, was effective in selectively eliminating stringent, conjugative, multidrug-resistant plasmids fromEscherichia coli strains. Simultaneous loss of resistance to antibiotics in plumbagin-treated cells indicated loss of plasmid. However, such R plasmids are refractory to treatment with acridine orange and sodium dodecyl sulfate, which are widely used in curing techniques. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|