Multibreath tracer species dynamics in the lung |
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Authors: | Gerald M Saidel Gerald M Burma |
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Institution: | (1) Dept. of Biomedical Engineering, Case Western Reserve University and Veterans Administration Medical Center, 44106 Cleveland, Ohio, U.S.A. |
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Abstract: | By studying the behavior of various tracer species in the lungs, one can assess many important characteristics which distinguish
normal and abnormal function. Quantitative evaluation of function depends on the use of an appropriate model in conjunction
with experimental data. A multi-compartment model is derived from mass balances to describe dynamic as well as (breath-averaged)
steady-state transport processes between the environment and pulmonary capillary blood. The breathing cycle is divided into
three time periods (inspiration, expiration, and pause) so that the model equations are discrete in time. No other model of
tracer species transport in the lungs deals simultaneously with species dynamics, variable breathing pattern, distribution
inhomogeneities, and non-equilibrium between alveolar gas and capillary blood. Models currently in the literature are shown
to be special cases of the model presented here. |
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Keywords: | |
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