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Protein function annotation by homology-based inference |
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| Authors: | Yaniv Loewenstein Domenico Raimondo Oliver C Redfern James Watson Dmitrij Frishman Michal Linial Christine Orengo Janet Thornton Anna Tramontano |
| Affiliation: | 1. Department of Biological Chemistry, The Hebrew University of Jerusalem, Sudarsky Center, Jerusalem, 91904, Israel 2. Department of Biochemical Sciences, University of Rome "La Sapienza", Rome, 00185, Italy 3. Research Department of Structural and Molecular Biology, University College, London, WC1E, UK 4. European Bioinformatics Institute, Hinxton, CB10 1SD, UK 5. Technische Universit?t, Munich, Germany 6. Helmholtz Zentrum, German Research Center for Environmental Health, Munich, 85764, Germany 7. Pasteur Institute-Cenci Bolognetti Foundation, University of Rome "La Sapienza", Rome, 00185, Italy |
| Abstract: | With many genomes now sequenced, computational annotation methods to characterize genes and proteins from their sequence are increasingly important. The BioSapiens Network has developed tools to address all stages of this process, and here we review progress in the automated prediction of protein function based on protein sequence and structure. |
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