Modification of shear modulus and creep compliance of fibrin clots by fibronectin |
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Authors: | Gregory W Kamykowski Deane F Mosher Laszlo Lorand John D Ferry |
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Institution: | 1. Departments of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA;2. Departments of Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA;3. Department of Biochemistry and Molecular Biology, Northwestern University, Evanston, Illinois 60201, USA |
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Abstract: | Shear moduli and creep compliances have been measured for four types of clots of human fibrin (about 7 ) clotted with and without human plasma fibronectin (usually 1.2 ). Fine clots (with little lateral aggregation of the fibrin protofibrils) were formed at pH 8.5, ionic strength 0.45 ; coarse clots (with substantial lateral aggregation) were formed at pH 7.5, ionic strength 0.15; in both cases with and without ligation by fibrinougase. In fine clots, the addition of fibronectin without ligation scarcely affected the shear modulus; with ligation, the modulus was decreased by a factor of 0.48. In coarse clots, the shear modulus was increased by addition of fibronectin. The increase was by a factor of 2.0 without ligation and by a factor of 2.4 with ligation. Creep and creep recovery in clots formed with and without fibronectin were similar except for the scale factor represented by the change in modulus. |
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