Subcellular Distribution of Homer 1b/c in Relation to Endoplasmic Reticulum and Plasma Membrane Proteins in Purkinje Neurons |
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Authors: | Sandonà Dorianna Scolari Alessandra Mikoshiba Katsuiko Volpe Pompeo |
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Institution: | (1) Dipartimento di Scienze Biomediche Sperimentali dell', Università degli Studi di Padova, viale G. Colombo 3, 35121 Padova, Italy;(2) Department of Molecular Neurobiology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokane dai, Minato-ku, Tokyo, 108-8639, Japan |
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Abstract: | The subcellular distribution of endoplasmic reticulum proteins (IP3R1 and RYR), plasma membrane(PM) proteins (mGluR1 and PMCA Ca2+-pump), and scaffolding proteins, such as Homer 1b/c, was assessed by laser scanning confocal microscopy of rat cerebellum parasagittal sections. There appeared to be two classes of Ca2+ stores, nonjunctional Ca2+ stores and junctional Ca2+ stores, possibly referable to central cisternae/tubules and sub-PM cisternae, respectively, in soma, dendrites, and dendritic spines. Only some IP3R1s appeared to be part of multimeric, junctional Ca2+ signaling networks, whose composition is shown to include PMCA, mGluR1, Homer 1b/c and, not always, RYR1. |
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Keywords: | Calcium signal transduction endoplasmic reticulum neuronal plasticity |
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