LTP mechanisms: from silence to four-lane traffic |
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Authors: | Malinow R Mainen Z F Hayashi Y |
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Institution: | Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. malinow@cshl.org |
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Abstract: | Brief periods of strong neuronal activity induce long-lasting changes in synaptic function. This synaptic plasticity is thought to play important roles in learning and memory. One example--long-term potentation in the CA1 region of the hippocampus--has been studied extensively, and conflicting views regarding the underlying mechanisms have emerged. Recent findings, regarding basic properties of synaptic transmission, appear to reconcile these diverging views. |
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