D-3-Hydroxybutyrate metabolism in the perfused rat heart |
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Authors: | A M N Sultan |
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Institution: | (1) Department of Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia |
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Abstract: | Summary The utilization of D-3-HB and the production of acetoacetate by the perfused rat heart were investigated over a wide range
of DL-3-HB concentrations. The rate of D-3-HB utilization is concentration dependent, and shows saturation kinetics. The oxidized
amount of D-3-HB when D-3-HB as a sole substrate, accounts at a maximum for 50% of the total oxygen consumption, which suggest
the contribution of the endogenous substrate as fuel source along with D-3-HB. The proportion of the D-3-HB consumed that
is oxidized rather than released as acetoacetate increases from 70% to 93% as the concentration of D-3-HB falls from 6.99
mM to 0.30 mM. |
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Keywords: | ketone bodies D-3-hydroxybutyrate acetoacetate perfused rat heart heart metabolism |
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