Experience with antirabies vaccination of foxes using the oral route coordinated among several European countries and perspectives on the use of recombinant vaccinia-rabies virus |
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| Authors: | P P Pastoret J Blancou B Brochier I Thomas A Paquot J Debruyn F Costy F Wolff M P Kieny B Languet |
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| Institution: | Département de Virologie-Immunologie et Pathologie des Maladies Virales, Faculté de Médecine Vétérinaire, Bruxelles, Belgique, France. |
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| Abstract: | Campaigns of fox vaccination against rabies were carried out in Belgium, grand-duchy of Luxembourg and France in September 1986, June and September 1987. The SAD B19 attenuated strain of rabies virus, contained in baits (Tübingen baits) was used as vaccine. Baits were distributed at a range density of 11 to 15 baits per km2. First results are very encouraging. A recombinant vaccinia virus harbouring the rabies virus glycoprotein gene has been developed. This recombinant virus can be given to the fox by the oral route and protects it against rabies virus challenge; it is also innocuous for the fox and other non-target European species. A first trial of fox vaccination against rabies using this recombinant vaccinia-rabies virus has been carried out in Belgium, on a military domain, in October 1987. |
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