Influence of vegetable oil vehicles on bone-marrow proliferation in the mouse micronucleus test |
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| Authors: | A P Simula B G Priestly |
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| Affiliation: | Department of Clinical and Experimental Pharmacology, University of Adelaide, Australia. |
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| Abstract: | The detection of genotoxins in the mouse bone-marrow micronucleus (MN) test is sensitive to factors which may inhibit bone-marrow proliferation. We have shown that three commercially available cooking oils (olive, peanut and sunflower seed oils), commonly used as vehicles in toxicological tests, were able to induce a cytotoxic effect in mouse bone marrow. The effects observed were reversible and the magnitude of the responses varied with the oil administered. The results suggest a need to examine vehicle effects when conducting the MN test. |
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