Gene expression profiles in the prefrontal cortex of SHR rats by cDNA microarrays |
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| Authors: | Jie Qiu Qin Hong Rong-hua Chen Mei-ling Tong Min Zhang Li Fei Xiao-qin Pan Mei Guo Xi-rong Guo Xia Chi |
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| Affiliation: | (1) Department of Pediatrics, Nanjing Maternity and Child Health Hospital of Nanjing Medical University, 210004 Nanjing, China;(2) Institute of Pediatrics of Nanjing Medical University, 210029 Nanjing, China |
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| Abstract: | We have undertaken cDNA microarrays to identify differentially expressed genes in the prefrontal cortex (PFC) of spontaneously hypertensive-rat (SHR), a rodent model of attention deficit hyperactivity disorder (ADHD) versus control Wistar-Kyoto (WKY) rats. The analysis of the gene expression profiles indicated that 57 genes were up-regulated and 97 genes were down-regulated in the PFC of SHR. These predominately expressed genes included genes involved in neural development, immunity, transcription factor, monoamine neurotransmitter, metabolism, signal transduction, apoptosis and so on. Although more detailed analyses are necessary, it is anticipated that further study of genes identified will provide insights into their specific roles in the etiology of ADHD. |
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