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Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy
Authors:Ling-dong Quan  P Edward Purdue  Xin-ming Liu  Michael D Boska  Subodh M Lele  Geoffrey M Thiele  Ted R Mikuls  Huanyu Dou  Steven R Goldring  Dong Wang
Institution:(1) Department of Pharmaceutical Sciences, 986025 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198-6025, USA;(2) Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA;(3) Department of Radiology, University of Nebraska Medical Center, Omaha, NE 68198-1045, USA;(4) Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA;(5) Department of Internal Medicine, Section of Rheumatology, University of Nebraska Medical Center, Omaha, NE 68198-3332, USA;(6) Omaha VA Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA;(7) Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA;(8) Department of Biomedical Sciences, Texas Tech University Health Sciences Center (TTUHSC), Paul L. Foster School of Medicine, COE for Infectious Diseases, MSB1, 5001 El Paso Drive, Room 4111, El Paso, TX 79905-2827, USA
Abstract:
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