Xenobiotic metabolism in the human lung |
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| Authors: | M E McManus A R Boobis G M Pacifici R Y Frempong M J Brodie G C Kahn C Whyte D S Davies |
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| Institution: | 1. Department of Clinical Pharmacology, Royal Postgraduate Medical School, Ducane Road, London W12 0HS, UK;1. London Chest Hospital, Bethnal Green, London E2, UK |
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| Abstract: | The metabolism of xenobiotics by human lung has been investigated in tissue obtained from 10 patients undergoing pneumonectomy and compared with human liver activities in 6 different subjects. Lung microsomal fractions contain no detectable cytochrome P-450 while cytochrome b5 values were 25% of those for human liver. NADH and NADPH-cytochrome c reductase activity are in the range of those reported for other species. Human lung microsomes possess < 3% of the metabolic activity of liver for the oxidation of benzpyrene, phenacetin and 7-ethoxycoumarin. |
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