A new sesquiterpene lactone from the roots of Saussurea lappa: structure-anticancer activity study |
| |
Authors: | Robinson A Kumar T Vijay Sreedhar E Naidu V G M Krishna Sistla Rama Babu K Suresh Srinivas P V Rao J Madhusudana |
| |
Institution: | aNatural Products Laboratory, Division of Organic Chemistry-1, Indian Institute of Chemical Technology, Hyderabad 500 607, India;bDivision of Pharmacology, Indian Institute of Chemical Technology, Hyderabad 500 607, India |
| |
Abstract: | The dried roots of Saussurea lappa, called costus roots, are used in the traditional system of medicine for the treatment of cancer. In our investigation for the anticancer constituents from the hexane extract of this plant, a new sesquiterpene (1) was isolated along with the known compounds costunolide (2), β-cyclocostunolide (3), dihydro costunolide (4) and dehydro costuslactone (5). Their structures were established by the extensive spectroscopic analyses. In addition, costunolide and β-cyclocostunolide derivatives were synthesized using Michael-type addition reaction of NaOMe to the α-methylene-γ-lactone moiety. All the compounds were tested for their in vitro cytotoxic activity. Compound 1 exhibited potent cytotoxic activity and other compounds displayed moderate activity. |
| |
Keywords: | Saussurea lappa Costus roots Anticancer activity Costunolide β -Cyclocostunolide |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|