Expression patterns of ADAMs in the developing chicken lens |
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Authors: | Xin Yan Juntang Lin Arndt Rolfs Jiankai Luo |
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Institution: | (1) Albrecht-Kossel-Institute for Neuroregeneration, School of Medicine University of Rostock, Gehlsheimer Strasse 20, 18147 Rostock, Germany;(2) Institute of Anatomy I, School of Medicine University of Jena, Teichgraben 7, 07743 Jena, Germany;(3) Department of Life Science and Technology, Xinxiang Medical University, Xinxiang, 453003, China; |
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Abstract: | In the present study the expression patterns of ADAM (a disintegrin and metalloprotease) genes in the chicken developing lens
were analyzed. Using in situ hybridization, we found that seven members of the ADAM family including ADAM9, ADAM10, ADAM12,
ADAM13, ADAM17, ADAM22, and ADAM23 are expressed in the developing embryonic lens. From embryonic incubation day (E) 2 to
E3, most of the ADAMs investigated here are expressed in the lens placode and lens vesicle. From E5 to E7, all seven ADAMs,
but predominantly ADAM9 and ADAM10, are throughly expressed in the central epithelium, as well as in the proliferating lens
epithelium and the equatorial lens epithelium. From E9 to E14, expression of ADAM9, ADAM10, and ADAM17 decreases moderately
in these regions. ADAM12 and ADAM13 are weakly expressed in the central epithelium and the lens epithelium, and are not detectable
from E14 onward. ADAM22 and ADAM23 are expressed in the central epithelium, the lens epithelium and the equatorial lens epithelium
at E5 and decrease gradually afterwards in the same regions. At E16, only weak ADAM9, ADAM10 and ADAM17 signals are found
in the anterior lens epithelium. The changing spatiotemporal expression of the seven ADAMs suggests a regulatory role for
these molecules during chicken lens development. |
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