Host response to mycobacterial cell wall subunit during experimental tuberculosis in mice |
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| Authors: | I B Chugh V K Vinayak G K Khuller |
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| Institution: | (1) Department of Biochemistry, Postgraduate Institute of Medical Education and Research, 160 012 Chandigarh, India;(2) Department of Experimental Medicine, Postgraduate Institute of Medical Education and Research, 160 012 Chandigarh, India |
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| Abstract: | The cell-wall protein-peptidoglycan complex (CW-PPC) ofMycobacterium tuberculosis, an immunologically potent component, was used to study the correlation between immune response andin vivo bacterial multiplication in the course of experimental tuberculosis infection in mice. Antibodies to CW-PPC were detected
only after seven weeks of infection withM. tuberculosis H37Rv and afterwards no significant change was seen throughout the experiment. Delayed type hypersensitivity (DTH) to CW-PPC
showed a gradual increase from the fifth week onward with a maximum during the 12th week after infection (p.in.) which did
not change significantly afterward. The increased immune response in the course of infection correlated well with the multiplication
rate of bacilli in the lungs. These results indicate a role of CW-PPC in antituberculous immunity. |
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