Comparative analysis of sensitivity of cholinesterases of different origin to monoonium reversible inhibitors

The analytic review of the literature data on constants of interaction of cholinesterases of different animal (vertebrates and squids) with 89 onium (ammonium, phosphonium, sulfonium) reversible inhibitors constituting homologous series with regularly varied structure is carried out. Values of the competitive, uncompetitive and generalized inhibitor constants are compared. On the basis of that, conclusions about the mechanism of action of the studied compounds and primary place of their sorption—in “anionic” or peripheral “anionic” sites of enzymes—are made. The presented data are considered from the point of view of comparative biochemistry and in light of current concepts of cholinesterase active center structure.