Progressive loss of neuronal src protein in postnatal weaver and staggerer cerebellum |
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Authors: | O D Wiestler E Trenkner G Walter |
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Institution: | Department of Pathology, University of California, School of Medicine, La Jolla. |
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Abstract: | Two forms of the c-src protein-tyrosine kinase, pp60c-src, are detectable in the central nervous system. One form pp60+, appears to be exclusively expressed in neurons and is characterized by insertion of 6 amino acids compared to its non-neuronal counterpart, pp60. These 2 proteins were studied in the mutant mouse strains weaver and staggerer with postnatal loss of cerebellar granular neurons. We found a continuous postnatal decline of the neuronal form of pp60c-src, pp60+, in the cerebellum of both mutants concomitant with the degeneration of cerebellar granule cells. This indicates that granular neurons provide the main source for pp60+ in the cerebellar cortex. |
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