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Characterization of the human primary visual cortex and cerebellum proteomes using shotgun mass spectrometry-data-independent analyses
Authors:Martins-de-Souza Daniel  Guest Paul C  Guest Francesca L  Bauder Corinna  Rahmoune Hassan  Pietsch Sandra  Roeber Sigrum  Kretzschmar Hans  Mann David  Baborie Atik  Bahn Sabine
Affiliation:Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.
Abstract:We present the first characterization of the human occipital lobe (primary visual cortex) and cerebellum proteomes. Proteins were identified using a combination of gel electrophoresis and data‐independent nanoflow liquid chromatography mass spectrometry (nLC‐MSE). The resulting data sets comprised 391 and 330 unique proteins in occipital lobe and cerebellum, respectively, present in at least 75% of the analyzed samples with 297 proteins found in common. These proteins have been associated previously with conditions, such as neurological disorder, progressive motor neuropathy, Parkinson's disease and schizophrenia. The unique proteins identified in the occipital lobe included the interesting finding of growth hormone and several members of the Ca2+‐dependent calmodulin kinase and serine/threonine protein phosphatase families. The complete mapping of these and other brain proteomes may help in the elucidation of neurological processes and identify potential targets for therapeutic strategies.
Keywords:Biomedicine  Brain  Cerebellum  Growth hormone  MS  Occipital lobe
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