ATM, a central controller of cellular responses to DNA damage. |
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| Authors: | K K Khanna M F Lavin S P Jackson T D Mulhern |
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| Institution: | The Queensland Institute of Medical Research, and Department of Pathology and Surgery, University of Queensland, PO Royal Brisbane Hospital, Brisbane, Qld4029, Australia. |
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| Abstract: | Mutations in the ATM gene lead to the genetic disorder ataxia-telangiectasia. ATM encodes a protein kinase that is mainly distributed in the nucleus of proliferating cells. Recent studies reveal that ATM regulates multiple cell cycle checkpoints by phosphorylating different targets at different stages of the cell cycle. ATM also functions in the regulation of DNA repair and apoptosis, suggesting that it is a central regulator of responses to DNA double-strand breaks. |
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