Inhibitory and lethal effects of chlorhexidine and a polymeric biguanide on some strains of Providencia stuartii |
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| Authors: | N ISMAEEL J R FURR A D RUSSELL |
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| Institution: | Pharmaceutical Microbiology Research Laboratory, Welsh School of Pharmacy, University of Wales Institute of Science and Technology, PO Box 13, Cardiff CF1 3XF, UK |
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| Abstract: | The effects of chlorhexidine diacetate and vantocil IB on the viability of Providencia stuartii strains are described. Exposure of Prov. stuartii strains to different concentrations of chlorhexidine in broth culture resulted in a decrease in viability over the first 6 h, followed by regrowth. During incubation, bacteria adhered to the surface of the culture vessel and multiplied despite the presence of a bactericidal concentration of the drug in the medium. It is concluded that the phenomenon of 'regrowth' results from adhesion to glass containers and the subsequent dispersal of some of these cells into the culture medium. |
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