| 接触系统生物学意义的再认识 |
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| 作者姓名： | Liu FY He SL |
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| 作者单位： | 湖南医科大学生理学教研室,长沙,410078 |
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| 摘 要： | 目前,凝血学说发放发生了概念性改变,认为体风凝血过程分为两个阶段?组织因子途径凝血过程的启动,以因子Ⅸ（ＦⅨ）为起点的内在途径凝血过程的放大,而接触系统并不参与体内凝血过程。已有资料表明,接触系统是一个重要的血管生物学调制 主要作用包括调整血管紧张度、抑制血小板活化、促进纤溶、抑制粘附以及促进炎病等。它的改变与败血症、血栓性疾病等病变过程密切相关。
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| 关 键 词： | 接触系统 细胞因子途径 血管生物学 调制系统 |
Revision of the biological significance of the contact system |
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| Liu FY,He SL.Revision of the biological significance of the contact system[J].Progress in Physiological Sciences,2000,31(1):7-12. |
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| Authors: | Liu F Y He S L |
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| Institution: | Department of Physiology, Hunan Medical University, Changsha 410078. |
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| Abstract: | Current concept of blood coagulation is divided into two stages: an "initiation" stage which is handled by tissue factor pathway, and an "augmentation" stage handled by intrinsic pathway beginning in factor XI. Recent studies have demonstrated that the contact system is a modulator for vascular biology with vascular tone regulation, anticoagulant, profibrinolytic, antiadhesive and proinflammatory functions. Changes of contact system are associated with sepsis, thrombosis, etc. |
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