| 细菌II型毒素-抗毒素系统活性的调控 |
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| 引用本文： | 孙瑞,宁德刚. 细菌II型毒素-抗毒素系统活性的调控[J]. 微生物学通报, 2016, 43(12): 2714-2719 |
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| 作者姓名： | 孙瑞 宁德刚 |
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| 作者单位： | 1. 江苏大学环境学院 江苏 镇江 212013；2. 中国科学院水生生物研究所 湖北 武汉 420072,1. 江苏大学环境学院 江苏 镇江 212013；2. 中国科学院水生生物研究所 湖北 武汉 420072 |
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| 基金项目： | 国家自然科学基金项目(No. 31471185)；淮安市协同创新项目(No. HAC2014022) |
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| 摘 要： | 细菌毒素-抗毒素系统(Toxin-antitoxin system,TA)由稳定的毒素和不稳定的抗毒素构成,几乎存在于所有细菌中。已证明染色体编码的II型TA系统作为胁迫反应因子,通过毒素作用于不同的细胞靶点来调控重要的细胞活动过程,使细菌适应不同的环境胁迫。因此,毒素活性的调控是II型TA系统介导细菌适应性胁迫反应的关键。本文总结了II型TA系统毒素活性调控机制的研究进展,并介绍了作者近年来对模式蓝藻Synechocystis sp.PCC6803中II型TA毒素活性调控的研究结果。
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| 关 键 词： | 细菌，毒素-抗毒素系统，毒素活性，调控 |
Regulation of activity of II-type toxin-antitoxin systems in bacteria |
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| SUN Rui and NING De-Gang. Regulation of activity of II-type toxin-antitoxin systems in bacteria[J]. Microbiology China, 2016, 43(12): 2714-2719 |
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| Authors: | SUN Rui and NING De-Gang |
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| Affiliation: | 1. School of the Environmental, Jiangsu University, Zhenjiang, Jiangsu 212013, China; 2. Institute of Hydrobiology, Chinese Acedemy of Sciences, Wuhan, Hubei 420072, China and 1. School of the Environmental, Jiangsu University, Zhenjiang, Jiangsu 212013, China; 2. Institute of Hydrobiology, Chinese Acedemy of Sciences, Wuhan, Hubei 420072, China |
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| Abstract: | Bacterial toxin-antitoxin (TA) systems are formed by a stable toxin and its cognate labile antitoxin, and exist almost in all bacteria. Recently, the chromosome-encoded II-type TA systems have been demonstrated to function as stress-response elements and help bacteria acclimate to different environmental stresses through the action of toxins to various cellular targets. Therefore, the modulation of toxin activities is crucial to II-type TA systems triggering bacterial response to environmental stresses. In this review, we describe the regulation mechanisms of II-type TA system activity, and briefly introduce our recent studies on the regulation of the II-type TA systems in the model cyanobacterium Synecocystis sp. PCC6803. |
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| Keywords: | Bacteria toxin-antitoxin system toxin activity regulation |
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