Effects of cycloSal-d4TMP derivatives in H9 cells with induced AZT resistance phenotype. |
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| Authors: | B Gr?schel C Meier R Zehner J Cinatl H W Doerr J Cinatl |
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| Affiliation: | Institute of Medical Virology, Johann Wolfgang Goethe University, Frankfurt/M., Germany. |
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| Abstract: | Cytotoxic and antiretroviral activity of cycloSal-d4TMP derivatives were tested in a new AZT-resistant H9 cell subline (H9rAZT250). The results showed, that cycloSal-d4TMP derivatives overcame resistance of HIV-1 to d4T in H9rAZT250 cells, which exert decreased thymidine kinase (TK) gene expression. |
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