Recombinant protein production in yeasts |
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| Authors: | Danilo Porro Michael Sauer Paola Branduardi Diethard Mattanovich |
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| Institution: | (1) Department of Biotechnology and Bioscience, University of Milano-Bicocca, p.zza della Scienza 2, 20126 Milano, Italy;(2) Institute of Applied Microbiology, BOKU-University of Natural Resources and Applied Life Sciences, Muthgasse 18, A-1190 Vienna, Austria |
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| Abstract: | Recombinant DNA (rDNA) technologies (genetic, protein, and metabolic engineering) allow the production of a wide range of
peptides, proteins, and biochemicals from naturally nonproducing cells. These technologies, now approx 25 yr old, have become
one of the most important technologies developed in the twentieth century. Pharmaceutical products and industrial enzymes
were the first biotech products on the world market made by means of rDNA. Despite important advances in rDNA applications
in mammalian cells, yeasts still represent attractive hosts for the production of heterologous proteins. In this review we
summarize advantages and limitations of the main and most promising yeast hosts. |
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| Keywords: | Yeasts heterologous proteins expression industrial biotechnology |
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