Two pathways of placental lactogen secretion by cultured human trophoblast |
| |
Authors: | Z Hochberg T Bick R Perlman |
| |
Affiliation: | Department of Pediatrics, Rambam Medical Center, Technion-Israel Institute of Technology, Haifa. |
| |
Abstract: | To assess the relative importance of regulated and of constitutive secretion of placental lactogen, a cell culture model of term human trophoblast was utilized. Time courses of secretion revealed a constant secretion rate over 9 days of culture, with relatively small constant intracellular hormone concentration. Potassium, 21 mM, produced a slight but significant increase in hormone secretion into the medium. Growth hormone-releasing hormone (5 X 10(-10)-5 X 10(-9)) stimulated a 27-48% increase in placental lactogen secretion. The data suggest a major process of constitutive secretion and a minor role for regulated secretion from a storage pool. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|