Self-peptide/MHC and TCR antagonism: physiological role and therapeutic potential |
| |
Authors: | Vukmanović Stanislav Santori Fabio R |
| |
Institution: | Center for Cancer and Immunology Research, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010-2970, USA. svukman@cnmc.org |
| |
Abstract: | TCR antagonists are peptides that bind MHC molecules and can specifically inhibit T cell activation induced by antigens. Studying TCR antagonism has taken an important place in immunology for both theoretical and practical reasons. Deciphering the mechanism(s) of action of TCR antagonists can yield important information about interactions of the TCR with ligands, T cell development, and TCR signaling. Moreover, microorganisms may employ TCR antagonism to elude the attention of the immune system. Finally, specificity of inhibition makes TCR antagonists an ideal tool to seek antigen-specific immunomodulation. Present state of knowledge on these topics is reviewed. |
| |
Keywords: | T cell receptor MHC Antagonism |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|