Discovery and synthesis of tetrahydroindolone derived semicarbazones as selective Kv1.5 blockers |
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| Authors: | Wu Shengde Fluxe Andrew Janusz John M Sheffer James B Browning Greg Blass Benjamin Cobum Keith Hedges Richard Murawsky Michael Fang Bin Fadayel Gina M Hare Michelle Djandjighian Laurent |
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| Institution: | Procter & Gamble Pharmaceuticals, Mason Business Center, 8700 Mason-Montgomery Road, Mason, OH 45040, USA. wu.s.3@pg.com |
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| Abstract: | A novel class of tetrahydroindolone-derived semicarbazones has been discovered as potent Kv1.5 blockers. In in vitro studies, several compounds exhibited very good potency for blockade of Kv1.5. Compound 8i showed good selectivity for blockade of Kv1.5 vs hERG and L-type calcium channels. In an anesthetized pig model, compounds 8i and 10c increased atrial ERP about 28%, 18%, respectively, in the right atrium without affecting ventricular ERP. |
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