Evolution and origin of merlin,the product of the <Emphasis Type="Italic">Neurofibromatosis type 2</Emphasis> (<Emphasis Type="Italic">NF2</Emphasis>) tumor-suppressor gene |
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| Authors: | Kseniya?Golovnina Alexander?Blinov Elena?M?Akhmametyeva Leonid?V?Omelyanchuk Email author" target="_blank">Long-Sheng?ChangEmail author |
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| Institution: | (1) Institute of Cytology and Genetics, Russian Academy of Sciences, 10 Lavrent'ev Ave., 630090, Novosibirsk, Russia;(2) Center for Childhood Cancer, Children's Research Institute, Children's Hospital and Department of Pediatrics, The Ohio State University, 700 Children's Drive, 43205-2696 Columbus, OH, USA |
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| Abstract: | Background Merlin, the product of the Neurofibromatosis type 2 (NF2) tumor suppressor gene, belongs to the ezrin-radixin-moesin (ERM) subgroup of the protein 4.1 superfamily, which links cell
surface glycoproteins to the actin cytoskeleton. While merlin's functional activity has been examined in mammalian and Drosophila models, little is understood about its evolution, diversity, and overall distribution among different taxa. |
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