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Industrial-scale production and purification of a heterologous protein in <Emphasis Type="Italic">Lactococcus lactis</Emphasis> using the nisin-controlled gene expression system NICE: The case of lysostaphin
Authors:Email author" target="_blank">Igor?MierauEmail author  Peter?Leij  Iris?van Swam  Barry?Blommestein  Esther?Floris  James?Mond  Eddy?J?Smid
Institution:(1) NIZO food research, P.O. Box 20, 6710, BA Ede, The Netherlands;(2) Biosynexus, Inc., 20877, 9119 Gaither Road, Gaithersburg, MD, USA
Abstract:

Background  

The NIsin-Controlled gene Expression system NICE of Lactococcus lactis is one of the most widespread used expression systems of Gram-positive bacteria. It is used in more than 100 laboratories for laboratory-scale gene expression experiments. However, L. lactis is also a micro-organism with a large biotechnological potential. Therefore, the aim of this study was to test whether protein production in L. lactis using the NICE system can also effectively be performed at the industrial-scale of fermentation.
Keywords:
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