Colorful Drying |
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Authors: | Satu Lakio Jyrki Heinämäki Jouko Yliruusi |
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Institution: | (1) Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland |
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Abstract: | Drying is one of the standard unit operations in the pharmaceutical industry and it is important to become aware of the circumstances
that dominate during the process. The purpose of this study was to test microcapsulated thermochromic pigments as heat indicators
in a fluid bed drying process. The indicator powders were manually granulated with α-lactose monohydrate resulting in three
particle-size groups. Also, pellets were coated with the indicator powders. The granules and pellets were fluidized in fluid
bed dryer to observe the progress of the heat flow in the material and to study the heat indicator properties of the indicator
materials. A tristimulus colorimeter was used to measure CIELAB color values. Color indicator for heat detection can be utilized
to test if the heat-sensitive API would go through physical changes during the pharmaceutical drying process. Both the prepared
granules and pellets can be used as heat indicator in fluid bed drying process. The colored heat indicators give an opportunity
to learn new aspects of the process at real time and could be exploded, for example, for scaling-up studies. |
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