Acyl-coenzyme A binding protein (ACBP) |
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Authors: | Kragelund B B Knudsen J Poulsen F M |
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Institution: | Carlsberg Laboratory, Department of Chemistry, Gl. Carlsberg Vej 10, DK-2500, Valby, Denmark. |
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Abstract: | Acyl-coenzyme A binding proteins are known from a large group of eukaryote species and to bind a long chain length acyl-CoA ester with very high affinity. Detailed biochemical mapping of ligand binding properties has been obtained as well as in-depth structural studies on the bovine apo-protein and of the complex with palmitoyl-CoA using NMR spectroscopy. In the four alpha-helix bundle structure, a set of 21 highly conserved residues present in more that 90% of all known sequences of acyl-coenzyme A binding proteins constitutes three separate mini-cores. These residues are predominantly located at the helix-helix interfaces. From studies of a large set of mutant proteins the role of the conserved residues has been related to structure, function, folding and stability. |
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