Roles of maternal HDL during pregnancy |
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| Affiliation: | 1. Department of Pathology and Laboratory Medicine, University of Cincinnati Medical School, Cincinnati, OH, United States of America;2. Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine and Magee Women''s Research Institute, Pittsburgh, PA, United States of America;3. Center for Research in Perinatal Outcomes, Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL, United States of America;4. Center for Research in Perinatal Outcomes, Department of Obstetrics and Gynecology, University of Florida, Gainesville, FL, United States of America;1. Department of Physiology & Biophysics, Boston University School of Medicine, Boston, MA 02118, USA;2. Endocrinology Department of the Hospital de la Santa Creu i Sant Pau, Barcelona, Spain;3. CIBER of Diabetes and Metabolic Diseases (CIBERDEM), Spain;4. Cardiovascular Biochemistry Group, Research Institute of the Hospital de Sant Pau, CIBERDEM, Barcelona, Spain;1. Department of Neurology and Neuroscience, Fujita Health University Hospital, Aichi, Japan;2. Faculty of Pharmacy, Laboratory of Biomembrane and Biofunctional Chemistry, Graduate School of Advanced Life Science and Frontier Research Center for Advanced Material and Life Science, Hokkaido University, Hokkaido, Japan;1. Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8505, Japan;2. Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima 770-8502, Japan;3. Diabetic Neuropathy Project, Department of Diseases and Infection, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan;1. Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria;2. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA;3. BioTechMed Graz, 8010 Graz, Austria;4. BioHealth Field of Excellence, University of Graz, 8010 Graz, Austria |
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| Abstract: | BackgroundHigh density lipoproteins (HDL) were first linked to cardiovascular disease (CVD) over 30 years ago when an inverse relationship was shown between CVD and HDL-cholesterol levels. It is now apparent that HDL composition and function, not cholesterol levels, are the pertinent measurements describing HDL's role in various disease processes, especially those with subclinical or overt inflammation.Scope of reviewPregnancy is also an inflammatory state. When inflammation becomes excessive during pregnancy, there is an increased risk for adverse outcomes that affect the health of the mother and fetus, including preterm birth and preeclampsia. Though studies on HDL during pregnancy are limited, recent evidence demonstrates that HDL composition and function change during pregnancy and in women with adverse outcomes.General significanceIn this review, we will discuss how HDL may play a role in maintaining a healthy pregnancy and how impairments in function could lead to pregnancies with adverse outcomes. |
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