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PCSK9 deficiency results in a specific shedding of excess LDLR in female mice only: Role of hepatic cholesterol
Institution:1. Institut de Recherches Cliniques de Montréal (IRCM), affiliated to the Université de Montréal, Montreal, QC, Canada;2. Equipe SP@RTE, UMR 6290 CNRS, Université de Rennes 1, Rennes, France;3. Nantes Université, CHU Nantes, CNRS, INSERM, l''Institut du thorax, F-44000 Nantes, France;4. Robarts Research Institute, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada;5. S.L. present address: Centre de recherche de l''hôpital Maisonneuve Rosemont, Montreal, QC, Canada;1. Univ. Grenoble Alpes, Inserm, LBFA, U1055, UFR STAPS, Grenoble, France;2. LBEPS, Univ Evry, IRBA, Université Paris Saclay, Evry, France;3. Aix Marseille Univ, CNRS, CRMBM, Marseille, France;4. Univ. Grenoble Alpes, Inserm, HP2, U1042, Grenoble, France;5. Univ. Grenoble Alpes, Inserm, LBFA, U1055, CHU Grenoble Alpes, Grenoble, France;6. Univ. Grenoble Alpes, Inserm, LBFA, U1055, Grenoble, France;1. Department of Biochemistry, Kagawa University School of Medicine, Kagawa, Japan;2. Department of Pathology, McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;3. Department of Environmental Biochemistry, Division of Biological Sciences, Kyoto Pharmaceutical University, Kyoto, Japan;4. Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;5. Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan;6. Department of Anatomy and Neurobiology, Kagawa University School of Medicine, Kagawa, Japan;7. Department of Pathology and Host Defense, Kagawa University School of Medicine, Kagawa, Japan;8. Department of Molecular Neurobiology, Kagawa University School of Medicine, Kagawa, Japan;9. Laboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo, Japan;1. Department of Biological Sciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia;2. Autoimmune Unit, Allergy and Immunology Research Centre, Institute for Medical Research (IMR), National Institute of Health (NIH) Malaysia, No. 1, Jalan Setia Murni U13/52, Bandar Setia Alam, 40170 Shah Alam, Selangor, Malaysia;3. Department of Food Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia;4. Innovation Centre for Confectionery Technology (MANIS), Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia;5. Colin Ratledge Center for Microbial Lipids, School of Agriculture Engineering and Food Sciences, Shandong University of Technology, 266 Xincun Rd., Zibo, Shandong, PR China;6. Department of Biological Sciences, University of Hull, Kingston upon Hull HU6 7RX, United Kingdom;1. Wihuri Research Institute, Haartmaninkatu 8, 00290 Helsinki, Finland;2. EV Group, Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Finland;3. CURED, Drug Research Program, Faculty of Pharmacy, Division of Pharmaceutical Biosciences, University of Helsinki, Finland;4. Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;5. Institute of Biomedicine, Department of Biochemistry and Developmental Biology, Meilahti Clinical Proteomics Core Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland;6. Helsinki Institute of Life Sciences, University of Helsinki, Helsinki, Finland;7. Minerva Foundation Institute for Medical Research, Biomedicum, Helsinki, Finland;8. National Institute for Health and Welfare, Helsinki, Finland;9. Molecular and Integrative Biosciences, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland
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