Recent advances in cytoplasmic lipid droplet metabolism in intestinal enterocyte |
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| Affiliation: | 1. Department of Anatomy, Physiology and Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada;2. Departments of Medicine and Physiology, University of Toronto, and University Health Network, Toronto, ON, Canada;1. College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China;2. Sanya Institute of Nanjing Agricultural University, Sanya, Hainan 572024, China;3. College of Animal Science, Fujian Agriculture & Forestry University, Fuzhou, Fujian 350002, China;1. Molecular Mechanisms of Cellular Stress and Inflammation, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA;2. Translational Analytical Core, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA;3. Mass Spectrometry Research and Support Group, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA;4. Neuroscience Center, Helsinki Institute for Life Science, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland;5. Cell and Tissue Dynamics Research Programme, Institute of Biotechnology, Helsinki Institute of Life Science, University of Helsinki, Finland;1. Blue California, Rancho Santa Margarita, CA 92688, USA;2. University of Cincinnati School of Medicine, Cincinnati, OH 45215, USA;3. Children''s Foundation Research Institute, Le Bonheur Children''s Hospital, University of Tennessee Health Science Center, Memphis, TN 38163, USA;1. Group on the Molecular and Cell Biology of Lipids and Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada;2. Institute of Atherosclerosis in Shandong First Medical University (Shandong Academy of Medical Sciences), Taian, China |
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| Abstract: | Processing of dietary fats in the intestine is a highly regulated process that influences whole-body energy homeostasis and multiple physiological functions. Dysregulated lipid handling in the intestine leads to dyslipidemia and atherosclerotic cardiovascular disease. In intestinal enterocytes, lipids are incorporated into lipoproteins and cytoplasmic lipid droplets (CLDs). Lipoprotein synthesis and CLD metabolism are inter-connected pathways with multiple points of regulation. This review aims to highlight recent advances in the regulatory mechanisms of lipid processing in the enterocyte, with particular focus on CLDs. In-depth understanding of the regulation of lipid metabolism in the enterocyte may help identify therapeutic targets for the treatment and prevention of metabolic disorders. |
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