Floridoside suppresses pro-inflammatory responses by blocking MAPK signaling in activated microglia |
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Authors: | MinJeong Kim Yong-Xin Li Pradeep Dewapriya BoMi Ryu Se-Kwon Kim |
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Institution: | 1.Department of Chemistry, Pukyong National University, Busan 608-737, Korea;2.School of Pharmacy, The University of Queensland, Brisbane, Qld 4072, Australia;3.Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Korea |
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Abstract: | Inflammatory conditions mediated by activated microglia lead to chronic neuro-degenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. This study was conducted to determine the effect of floridoside isolated from marine red algae Laurencia undulata on LPS (100 ng/ml) activated inflammatory responses in BV-2 microglia cells. The results show that floridoside has the ability to suppress pro-inflammatory responses in microglia by markedly inhibiting the production of nitric oxide (NO) and reactive oxygen species (ROS). Moreover, floridoside down-regulated the protein and gene expression levels of iNOS and COX-2 by significantly blocking the phosphorylation of p38 and ERK in BV-2 cells. Collectively, these results indicate that floridoside has the potential to be developed as an active agent for the treatment of neuro-inflammation. BMB Reports 2013; 46(8): 398-403] |
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Keywords: | Alzheimer’ s disease Floridoside Laurencia undulata Neuro-inflammation Oxidative stress |
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