Identification of QTLs Involved in the Development of Amygdala Kindling in
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| Authors: | Ryoko Hashimoto Birger Voigt Yuji Ishimaru Ryoji Hokao Shigeru Chiba Tadao Serikawa Masashi Sasa Takashi Kuramoto |
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| Affiliation: | 1)Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan;2)Department of Psychiatry and Neurology, Asahikawa Medical College, 2-1-1-1 Midorigaoka higashi, Asahikawa 078-8510, Japan;3)Institute of Animal Reproduction, 1103 Fukaya, Kasumigaura 300-0134, Japan |
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| Abstract: | Amygdala kindling is useful for modeling human epilepsy development. It has been knownthat genetic factors are involved in the development of amygdala kindling. The purpose ofthis study was to identify the loci that are responsible for the development of amygdalakindling. To achieve this, rat strains from a LEXF/FXLE recombinant inbred (RI) strainpanel were used. The phenotypes of amygdala kindling-related parameters for seven RIstrains and parental LE/Stm and F344/Stm strains were determined. They included theafterdischarge threshold (ADT), the afterdischarge duration (ADD), and the kindling rate,an incidence of development of kindling. Quantitative trait loci (QTL) analysis wasperformed to identify linkage relationships between these phenotypes and 1,033 SNPmarkers. Although no significant differences in pre-kindling ADT and ADD were observed, asignificant difference in the kindling rate was found for the LEXF/FXLE RI strain. TwoQTLs for the amygdala kindling rate (Agkr1 and Agkr2)were identified on rat chromosome 2. These findings clearly prove the existence of geneticinfluences that are involved in kindling development and suggest that substantial geneticcomponents contribute to the progression of partial seizures into generalizedseizures. |
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| Keywords: | amygdala kindling quantitative trait loci recombinant inbred strains temporal lobe epilepsy |
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