Labeling of RNA in young and adult rat brain: Evidence for different RNA processing |
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| Authors: | I Serra A Cupello M N Gadaleta M Viola P Ragonese A M Giuffrida |
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| Institution: | (1) Center for Cerebral Neurophysiology, C.N.R., Genova, Italy;(2) Institute of Biochemistry, University of Bari, Italy;(3) Institute of Biochemistry, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy |
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| Abstract: | The labeling of RNA in young and adult rat brain has been studied by measuring in vitro (tissue slices incubation) the incorporation of labeled uridine into RNA of total tissue and of the various subcellular fractions purified from cerebral hemispheres of 1- and 10-month-old rats. Gel electrophoretic analysis of the newly synthesized nuclear and microsomal RNA was also accomplished. An active metabolism of RNA in adult animals was found; moreover, distinct differences in ribosomal RNA processing in cerebral hemispheres of 1- and 10-month-old rats, with a more rapid processing in the brain of adult animals, were obtained. |
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