(1) Department of Rheumatology, University Hospital Leiden, Building 1, PO box 9600, NL-2300 RC Leiden, The Netherlands;(2) Department of Immunohematology and Blood Bank, University Hospital Leiden, Leiden, The Netherlands
Abstract:
We have identified a C-insertion polymorphism in the 5'UTR of the first exon of the human tumor necrosis factor alpha (TNFA) gene. TNFA is a cytokine that plays an important role in the inflammatory response.