| 哺乳动物卵母细胞老化的研究进展 |
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| 引用本文： | 王建英,万发春,孟小倩,张秀美. 哺乳动物卵母细胞老化的研究进展[J]. 动物学杂志, 2009, 44(2): 147-152 |
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| 作者姓名： | 王建英 万发春 孟小倩 张秀美 |
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| 作者单位： | 1. 山东省农业科学院畜牧兽医研究所,畜禽疫病防治和繁育重点实验室,济南,250100
2. 山东师范大学生命科学学院动物抗性重点实验室,济南,250014 |
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| 基金项目： | 山东省农业科学院创新基金，山东省农业良种工程项目，山东省中青年科学家科研奖励基金，山东省博士后创新项目专项资金 |
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| 摘 要： | 卵母细胞的老化能够导致妊娠率降低、流产率增加和出生缺陷.研究排卵后卵母细胞在老化过程中发生的变化及卵母细胞老化的机制,探讨延缓卵母细胞老化的有效措施,对于改进卵母细胞体外成熟和受精系统,完善辅助生殖技术并减少出生缺陷具有重要的理论和现实意义.本文将从卵母细胞老化研究所用的方法,老化过程中纺锤体相关蛋白、线粒体、泛素、组蛋白修饰和DNA甲基化修饰的变化,卵母细胞老化与皮质反应、多精受精及凋亡的关系,老化的影响因素和分子机制等几个方面对哺乳动物卵母细胞老化的研究进展做一综述.
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| 关 键 词： | 哺乳动物 卵母细胞 老化 |
| 收稿时间： | 2008-08-13 |
| 修稿时间： | 2008-12-30 |
Mammalian Oocyte Aging:a Review |
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| WANG Jian-Ying,WAN Fa-Chun,MENG Xiao-Qian and ZHANG Xiu-Mei. Mammalian Oocyte Aging:a Review[J]. Chinese Journal of Zoology, 2009, 44(2): 147-152 |
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| Authors: | WANG Jian-Ying WAN Fa-Chun MENG Xiao-Qian ZHANG Xiu-Mei |
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| Affiliation: | Key Laboratory of Animal Disease Control and Breeding,Animal Husbandry/Vet Institute,Shandong Academy of Agricultural Science,Jinan 250100;Key Laboratory of Animal Disease Control and Breeding,Animal Husbandry/Vet Institute,Shandong Academy of Agricultural Science,Jinan 250100;Key Laboratory of Animal Resistance Research,College of Life Science,Shandong Normal University,Jinan 250014,China;Key Laboratory of Animal Disease Control and Breeding,Animal Husbandry/Vet Institute,Shandong Academy of Agricultural Science,Jinan 250100 |
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| Abstract: | Oocyte aging induces low pregnancy,increases abortion and causes more birth defects.In order to optimize the system for in vitro maturation and fertilization of oocytes,improve assisted reproductive technology(ART) and lower birth defects,it is theoretically and practically important to study the changes and mechanism of oocyte aging,and to explore the effective method for retarding this process.Thereby we make a brief review of the methods for oocyte aging studies,changes of spindle-associated proteins,mit... |
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| Keywords: | Mammalian Oocyte Aging |
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