The P-loop--a common motif in ATP- and GTP-binding proteins |
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Authors: | M Saraste P R Sibbald A Wittinghofer |
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Institution: | European Molecular Biology Laboratory, Heidelberg, FRG. |
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Abstract: | Many ATP- and GTP-binding proteins have a phosphate-binding loop (P-loop), the primary structure of which typically consists of a glycine-rich sequence followed by a conserved lysine and a serine or threonine. The three-dimensional structures of several ATP- and GTP-binding proteins containing P-loops have now been solved. In this review current knowledge of P-loops is discussed with the additional aim of illustrating the fascinating relationship between protein sequence, structure and function. |
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