A synthetic strategy for ON-resin amino acid specific multiple fatty acid acylation of peptides |
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Authors: | Harishchandran Avaronnan Pallavi Bhattaram Nagaraj Ramakrishnan |
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Institution: | Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India. |
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Abstract: | Covalent modification with fatty acids is observed in several proteins that play crucial roles in cellular physiology. In this paper, a convenient method for the generation of multiple fatty acylated synthetic peptides is described. Peptides were synthesized using solid phase procedures with fluorenylmethoxycarbonyl a-amino protected amino acids. Acetamidomethyl protected cysteines were employed. The thiol protecting group was selectively deprotected and acylation was carried out on the resin-bound peptides. The strategy described in this report is applicable to any peptide sequence. |
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