Effects of various physiologic adenine derivatives on the secretion of acid in isolated gastric glands in rabbits |
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| Authors: | L F Ainz C E Gil-Rodrigo R Gómez M Malillos D Requejo J M Gandarias |
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| Affiliation: | Departamento de Fisiología, Facultad de Medicina y Odontología, Universidad del País Vasco, Bilbao, Espa?a. |
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| Abstract: | The physiological adenine derivatives, adenosine (ADO), adenosine 5'-monophosphate (AMP), adenosine 5'-diphosphate (ADP) and adenosine 5'-triphosphate (ATP) at concentrations ranging from 10 microM to 1 mM caused concentration-related modifications on gastric H+ secretion, as measured by the aminopyrine accumulation method, in resting and histamine-stimulated rabbit gastric glands. In resting glands, ADO caused significant concentration-related increases of the basal H+ secretion, whereas no changes were obtained in response to the other purines tested. In histamine-stimulated glands, ADO and AMP caused concentration-related potentiation of the histamine-raised H+ secretory rate, while ATP and ADP induced graded inhibition. The results suggest the involvement of purinergic mechanisms in the physiological regulation of the gastric acid secretory process. |
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