老年患者血培养病原菌分布及耐药性调查

目的了解老年患者血液感染的病原菌种类以及对抗菌药物的耐药状况。方法对2290份老年住院患者血培养标本中186例培养阳性检出菌及药敏结果进行统计学分析。结果在分离的172株细菌中,革兰阴性菌、革兰阳性菌及真菌分别占54.7%、34.9%和10.5%;革兰阴性菌中以大肠埃希菌占绝对优势(20.9%),假单胞菌其次(10.5%),革兰阳性菌中以凝固酶阴性葡萄球菌(CNS)占绝对优势(20.9%),金黄色葡萄球菌仅为2.9%。药敏试验表明老年菌血症的病原菌对常用抗菌药物的耐药严重,尤其是CNS及假单胞菌属细菌表现为较高的耐药率及多重耐药性。结论老年菌血症病原菌以机会致病菌感染比例较高,致病菌耐药问题严重,及时监测老年致病菌的变迁和耐药发展趋势以指导临床用药至关重要。

Clinical analysis of drug resistance and distribution of pathogens in senile septicemia patients

Objective To investigate the spectra and their drug resistance of bacteria strains in senile septicemia patients.Methods The bacteria isolated from 186 senile septicemia patients' blood were cultured and their antibiotic susceptibility was tested,and the drug resistance and distribution of pathogens were analyzed.Results Among the 172 bacterial strains,the percentage of Gram-negative bacteria,Gram-positive bacteria and fungi were 54.7%,34.9% and 10.5% respectively.The most common bacteria were Escherichia coli(20.9%),Coagulase-negative staphylococci(20.9%)and Pseudonmonas(10.5%).There were the high antibiotic resistance rates in the pathogenic bacteria.Conclusions The spectra and their drug resistance characteristics of pathogenic bacteria in senile septicemia should be emphasized,that is important to the application of antibiotics.