|
|||||
|
|
Novel cyanoguanidines with potent oral antitumour activity |
|
| Authors: | Charlotte Schou,Erik R. Ottosen,Hans Jø rgen Petersen,Fredrik Bjö rkling,Scilla Latini,Pernille V. Hjarnaa,Erik Bramm,Lise Binderup |
| Affiliation: | a Department of Chemistry, Leo Pharmaceutical Products, Industriparken 55, DK-2750, Ballerup, Denmark b Department of Biochemistry, Leo Pharmaceutical Products, Industriparken 55, DK-2750, Ballerup, Denmark c Department of Pharmacology, Leo Pharmaceutical Products, Industriparken 55, DK-2750, Ballerup, Denmark |
| Abstract: | 4-Pyridyl cyanoguanidines with hydrophobic aromatic side chains showed potent antiproliferative activity in the human breast and lung cancer cell lines MCF-7, NYH and H460. In vivo, treatment with N-(6-chlorophenoxyhexyl)-N′-cyano-N″-4-pyridylguanidine (18, 20 mg/kg/day po.), gave a complete remission of tumours in a model of NYH inoculated nude mice. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |